Sponsored Content by Advanced Bionutritionals. This article includes affiliate links, which may earn us a commission, to support truthful and independent journalism (at no extra cost to you).
Three scientists won the Nobel Prize in 1998 for discovering a molecule that keeps you young.
But by the age of 70, most people have already lost 75% of it.¹
If you’re over 50 and dealing with:
- Low energy
- Memory issues
- Cold hands
- Rising blood pressure
You’ve probably been told it’s just part of getting older… but research suggests there is something you can do about it.
The Nobel Prize-Winning Discovery That Explains Why You Age Faster
The Nobel Prize in Medicine was awarded to three scientists for identifying a molecule that controls blood flow throughout your entire body.
That molecule is nitric oxide.
Nitric oxide is a gas your body produces naturally, signaling to your blood vessels to relax and widen, which allows oxygen and nutrients to reach every cell, tissue, and organ in your body.
When nitric oxide levels are healthy, your body functions the way it should: your energy stays high, your memory stays sharp, and your blood pressure stays within the healthy range.
You can also boost nitric oxide naturally by:
- Breathing through your nose
- Eating foods rich in nitrates (beets, spinach, dark chocolate, etc.)
- Exercising
- Sunlight
But here’s the problem.
By around age 60–70, nitric oxide production can decline by up to ~75% compared to young adults.
This means that some of the natural ways of increasing nitric oxide may not be enough to have a meaningful anti-aging effect as we get older.
Why Most Nitric Oxide Boosters Don’t Work
Many people try to boost nitric oxide with supplements as it can be difficult to ensure we get enough through our diet.
Even if you are eating the right foods in the right amounts, your body’s ability to convert those nitrates into nitric oxide declines with age.²
Furthermore, most pills and capsules that are supposed to enhance nitric oxide are typically not fully absorbed by your body (L-Arginine is an example).³
The Lozenge Breakthrough
Scientists at the University of Texas Health Science Center developed a solution to the absorption inadequacies many nitric oxide supplements have.
They created an oral lozenge that dissolves on your tongue and mixes with the bacteria in your mouth which immediately kickstarts nitric oxide production.
They found it improved blood flow by 34% in just 10 minutes.⁴
This is the kind of improvement people can actually feel when it comes to some of the symptoms mentioned previously.
(Reader Note: The bacteria in your mouth are extremely important for nitric oxide production. Strong antiseptic/antibacterial mouthwashes have been shown to significantly reduce the bacteria in your mouth that help your body produce nitric oxide, which can impact blood pressure.⁵ Additionally, fluoride toothpaste may influence the balance of your oral microbiome.)
You can now get the high-quality nitric oxide lozenge Circ02 from the doctor-formulated supplement company, Advanced Bionutritionals.
What Makes CircO2 Different
CircO2 combines the lozenge delivery system with five key ingredients designed to boost nitric oxide production and protect the cells that produce it:
Beet Root Powder – Rich in natural nitrates that studies show can significantly increase nitric oxide levels.
Hawthorn Berry Extract – Protects blood vessel cells from damage and supports healthy circulation. In fact, it protects endothelial cells up to 6 times more than other medicinal herbs.⁶
L-Citrulline – Converts to nitric oxide more effectively than L-arginine (the base of most nitric oxide supplements), without losing potency during digestion.⁷
Vitamin B12 – Supports nitric oxide production and cognitive health (many people over 50 are deficient).
Vitamin C – Acts as a catalyst for nitric oxide production and protects against oxidative stress.
Advanced Bionutritionals is led by anti-aging physician Dr. Frank Shallenberger, doctor of traditional Chinese medicine Janet Zand, and naturopaths Dr. Greg Eckel and Dr. Steve Kroening.
The team at Advanced Bionutritionals is so confident in the benefits of CircO2 that they provide a 90-day money-back guarantee—you can even return empty bottles and get a full refund.
In addition, with our link you can get a $10 discount on your first bottle and access their bulk options where you can save when ordering multiple bottles.
What Some Users Are Experiencing
While individual results vary, people using CircO2 have reported a range of experiences that align with the potential benefits of restored nitric oxide levels.
Support for Healthy Blood Pressure – Some users report improved blood-pressure readings after using CircO2 consistently, though results differ from person to person.
Increased Energy and Stamina – Many users mention feeling less fatigued throughout the day, with more sustained energy for activities they enjoy. There’s a reason why many athletes use nitric oxide supplements prior to their workouts.
Mental Clarity and Focus – Some users notice improvements in focus and memory—particularly when it comes to remembering names, staying sharp in conversations, and maintaining mental energy later in the day.
Improved Circulation – People with cold hands and feet sometimes report feeling warmer extremities. Others mention experiencing relief from tightness or numbness.
Better Sleep Quality – A number of people report falling asleep more easily and waking up feeling more rested.
These benefits some people have experienced align with what we know about nitric oxide’s role in supporting blood flow—and how important optimal blood flow is for your entire body.
Is CircO2 Right For You?
CircO2 is designed for anyone looking to support healthy blood pressure and improve physical & mental performance.
It’s especially useful for people over 50 who are experiencing symptoms of age-related decline due to declining levels of nitric oxide.
If you’re experiencing fatigue, memory issues, elevated blood pressure or tightness/numbness in the hands and feet, supplementing with Circ02 may be of benefit.
CircO2 is available directly from Advanced Bionutritionals, a doctor-led supplement company specializing in science-backed formulas for healthy aging. They offer supplements for cognition, bone support, detoxification, and much more.
You can check out their catalog for other supplements here.
Once again, Advanced Bionutritionals offers a 90-day money-back guarantee so you can try CircO2 without any financial risk. They will even honor the refund if you return empty bottles.
In addition by using our link, you’ll receive $10 off your first bottle and will unlock their bulk options where you can save on multiple bottles.
Check out the benefits of Circ02 today.
Sources:
The following studies are provided for general informational purposes and are not specific to CircO2
¹ Torregrossa AC, Aranke M, Bryan NS. Nitric oxide and geriatrics: implications in diagnostics and treatment of the elderly. J Geriatr Cardiol. 2011;8(4):230–242.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3390088/
² Yang Z, Du C, Chang Z, Yang Y, Hu L. Role of oral and gut microbiomes in enterosalivary nitrate metabolism and their effects on systemic disease. Front Cell Infect Microbiol. 2025;15:1612223.
³ Gonzalez AM, Townsend JR, Pinzone AG, Hoffman JR. Supplementation with nitric oxide precursors for strength performance: a review of the current literature. Nutrients. 2023;15(3):660.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9921013/
⁴ Houston M, Hays L. Acute effects of an oral nitric oxide supplement on blood pressure, endothelial function, and vascular compliance in hypertensive patients. J Clin Hypertens (Greenwich). 2014;16(7):524–529
https://onlinelibrary.wiley.com/doi/full/10.1111/jch.12352
⁵ Kapil V, Haydar SM, Pearl V, et al. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med. 2013;55:93–100.
https://pubmed.ncbi.nlm.nih.gov/23183324/
⁶ Ling S, Nheu L, Dai A, Guo Z, Komesaroff P. Effects of four medicinal herbs on human vascular endothelial cells in culture. Int J Cardiol. 2008 Aug 29;128(3):350–358.
https://pubmed.ncbi.nlm.nih.gov/17692965/
⁷ Suzuki T, Morita M, Kobayashi Y, et al. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13:6.
https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0117-z
Disclaimers:
| †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. |
Update: This sponsored content was updated to indicate the accurate list of ingredients in the product.
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